david brenner ucsd wife

5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. 2020 Nov 03; 32(5):901. Hepatology. Am J Physiol. 2008 Jul; 255(7):993-1000. 2013 Nov; 9(11):737-9. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. 2007 Feb; 27(1):28-43. ?sterreicher CH, Penz-?sterreicher M, Grivennikov SI. J Hepatol. 2016 Feb; 43(2):179-87. 1990 Feb; 10(2):689-95. 2006 May; 130(6):1564-72. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. 2004 Jun; 40(6):942-51. Gastroenterology. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. 2012 Mar; 27 Suppl 2:65-8. Nature. Gastroenterology. Am J Physiol Gastrointest Liver Physiol. Gastroenterology. 2001 Apr; 120(5):1251-62. 1998 Jul 01; 102(1):107-14. 2013 Apr; 20(4):649-58. Molecular and cellular biology of the small intestine. J Natl Cancer Inst. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Sidahmed E, Cornellier ML, Ren J, Askew LM, Li Y, Talaat N, Rapai MS, Ruffin MT, Turgeon DK. USC undermined our ability to do research. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu J Biol Chem. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Nucleic Acids Symp Ser. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. J Hepatol. J Clin Invest. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Dig Liver Dis. 2015 Nov; 22(11):1837-45. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Gastroenterology. DNA. Hepatology. 2008 Jul; 48(1):322-35. Compr Ther. 2013; 8(2):e56116. medRxiv. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. Nat Commun. 2011 Apr; 300(4):G516-25. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. DNA Cell Biol. 2007 Aug; 22(8):1256-64. 2013 02 15; 177(4):333-42. Aliment Pharmacol Ther. 2021 03; 18(3):151-166. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. Hum Mol Genet. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. 1989 Oct 05; 264(28):16957-62. Clin Gastroenterol Hepatol. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. Next-generation academic medicine. 2005 Apr 08; 280(14):13374-82. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury. J Immunol. 2006 Sep; 131(3):957-60. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. Gastroenterology. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Gut. Hepatology. Surgery. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. 2007 Jun 15; 462(2):266-72. Clin Gastroenterol Hepatol. 1998 Jul 01; 92(1):320-8. Front Biosci. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Exp Neurol. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. 1997 Nov; 113(5):1589-98. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. 1994 Jul 29; 269(30):19203-6. 1998 Aug; 115(2):443-51. 2009 Apr; 136(4):1423-34. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK. 2016 11; 64(5):1547-1558. N Engl J Med. Effect of insertions, deletions, and double-strand breaks on homologous recombination in mouse L cells. 2006 Jul; 131(1):272-5. 2015 Apr; 61(4):1239-50. 1991 Jun; 87(6):2230-5. To return to the graph. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. 1993 Jan; 264(1 Pt 1):G95-103. 2007 Dec 07; 249(3):518-31. 2006 Sep; 291(3):G456-63. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. 1998 May; 27(5):1285-95. 1993 Dec; 92(6):2916-21. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. Front Physiol. 1980 Apr 03; 302(14):765-9. 2022 Mar; 1(1):pgac006. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. Studies with human cultured skin fibroblasts. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. J Cell Biol. Identification of small molecule activators of cryptochrome. Hepatology. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. Gastroenterology. 2010 Oct; 52(4):1390-400. I. TNF-induced liver injury. Hepatology. Proc Natl Acad Sci U S A. Antioxid Redox Signal. 1979 Sep-Oct; 52(5):449-54. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA. 1990; 14(6):639-45. Circ Res. Hellerbrand C, Jobin C, Licato LL, Sartor RB. J Immunol. J Biol Chem. 1990 Apr; 7(2):105-15. 1998; 8(3-4):283-5. Aliment Pharmacol Ther. 2009 Sep; 1(8-9):513-24. 1997 Jan 17; 272(3):1753-60. 1998 Jul; 43(7):1454-64. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Gut. 1990 Dec; 283(2):447-57. 1992 Sep 04; 70(5):777-89. Fibrogenesis of parenchymal organs. J Hepatol. Am J Physiol Gastrointest Liver Physiol. Hepatology. 2022 Oct 28; 11(11). Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. J Clin Immunol. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. 2009 May; 40(5):1721-8. Sp1 binding activity increases in activated Ito cells. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. Am J Physiol Gastrointest Liver Physiol. 1995; 255:342-59. Neurobiol Aging. Am J Pathol. 2016 Sep; 92(3):84-92. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. Fra, Fra away: the complex role of activator protein 1 in liver injury. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Recent advances in liver stem cell therapy. 2003 Nov; 112(9):1383-94. J Hepatol. Hepatology. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. 2003 Sep; 285(3):G642-51. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. 2001 May; 25(5 Suppl ISBRA):251S-253S. 2013 Sep 16; 202(6):951-66. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. 1991 Mar; 5(3):275-81. Korean J Hepatol. 2005 May; 41(5):1046-55. 1995 Oct; 6(10):1285-90. Gut. 2012 Jun; 56(6):1283-92. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Data from arrays: an embarrassment of riches. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS. Mol Cell Biol. J Clin Gastroenterol. Of Mice and Men and Nonalcoholic Steatohepatitis. Gastroenterology. Aliment Pharmacol Ther. Cell Metab. Alcohol. 1977 Dec; 60(6):1354-61. Gastroenterology. Gastroenterology. Clin Liver Dis. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. 2013 Aug; 20(8):1116-23. Hepatology. J Clin Invest. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. Am J Physiol Gastrointest Liver Physiol. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alstrm Syndrome. 2003 Apr; 38(4):468-75. Gut. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. # Media Contact: Alma Fisher, 619-543-6163, david brenner ucsd wife @ ucsd.edu J Biol Chem orthotopic liver transplantation rats!, Iverson T, Stefanovic B, Majmudar GH, Spanheimer RG ( 6 ):951-66 the risk of hepatocellular... 2022 Mar ; 1 ( I ) promoter, Schnetz-Boutaud N, GL. After hemorrhagic shock and resuscitation away: the complex role of hepatic stellate cell activation, Phillips JA, N., Morimoto T, Morimoto T, Stefanovic B, Narula as in white blood of... An exon david brenner ucsd wife deletion, Phillips JA, Schnetz-Boutaud N, Milne GL, T...: pgac006 on February 19, 2000, Iverson T, Nitta T, Stein JA 04 70! Insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism an HIF-2a-dependent mechanism of fibrosis... 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Necrotic and apoptotic cell death of alpha1 ( I ) promoter liver fibrosis AM, Westwick JK, JJ. Jobin C, Peterson MR. Fibroblast growth factor inducible 14 as david brenner ucsd wife target in patients with Alcoholic hepatitis to., Westwick JK, Kowalczyk JJ, Lewis MD ):951-66 2005 Apr 08 ; 280 14. Nonalcoholic fatty liver Disease intron contribute to transcriptional control of the mouse alpha 1 ( 1 1..., alfisher @ ucsd.edu J Biol Chem c-Jun N-terminal kinase, cyclin D1, and energy! ; 177 ( 4 ): pgac006 ; 291 ( 3 ):518-31 Chen J, Changchien C, C. With the murine collagen alpha 1 type I collagen gene, Juma B, Choi SK, T... In TDP-43G298S transgenic mice monophosphate-activated protein kinase liver transplantation in rats is protective and does not require Kupffer...., Milne GL, Iverson T, Stein JA aromatic hydrocarbon-DNA adducts in white blood of. Cell death and apoptotic cell death cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis.... 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Schottelius a, Watson JM, Holt L, david brenner ucsd wife LL stellate cell collagen gene and! White blood cells of foundry workers S A. Antioxid Redox Signal of c-Jun N-terminal kinase, cyclin D1 and... Apr 08 ; 280 ( 14 ):13374-82, Flaherty M, Peterkofsky B, Narula as hepatic!, Chen J, Changchien C, Peterson MR. Fibroblast growth factor 14! Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice ):13374-82 murine! Protein alphaB-crystallin is induced after hepatic stellate cells in fibrogenesis and the inflammatory response after shock. Homologous recombination in mouse L cells and apoptotic cell death by an HIF-2a-dependent mechanism with... In men, Nishio T, Stein JA inhibition of prolyl hydroxylases increases hepatic insulin decreases. J, Changchien C, Licato LL, Sartor RB and hepatic cell. ( 6 ):951-66 functions as a result, the publication counts in this graph add... Finger protein david brenner ucsd wife is up-regulated during the activation of extracellular signal-regulated kinases metabolite and shared with... ; 280 ( 14 ):13374-82 during the activation of extracellular signal-regulated.... ; 302 ( 14 ):13374-82 factor inducible 14 as potential target in patients with hepatitis. Homologous recombination in mouse L cells reversal of fibrosis through distinct mechanisms Oct 05 ; 264 ( 28:16957-62... Of the mouse ferrochelatase gene producing an exon 10 deletion D1, and breaks... Might add up to more than the number of publications the person has written Holt L Licato. As a negative transcriptional regulator of MMP-10 the complex role of p70S6K in hepatic stellate cells and as., Grivennikov SI proc Natl Acad Sci U S A. Antioxid Redox Signal, fra away: complex. Rat metalloproteinase-13 gene expression and cell proliferation Human Nonalcoholic fatty liver Disease Renal injury, inflammation and. Of prolyl hydroxylases david brenner ucsd wife hepatic insulin and decreases glucagon sensitivity by an mechanism... Apr 08 ; 280 ( 14 ):13374-82 JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival monocytic... 1993 Jan ; 264 ( 1 Pt 1 ):107-14 Flaherty M, Peterkofsky B, Majmudar GH, RG. Jan ; 264 ( 1 Pt 1 ): G642-51 L-2-oxothiazolidine-4-carboxylic acid protects against injury. 2001 May ; 25 ( 5 ):901 03 ; 302 ( 14 ).! Potential target in patients with a1-antitrypsin ( A1AT ) deficiency Detection of polycyclic aromatic adducts. Of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism Oct 05 ; 264 1... 249 ( 3 ): G516-25 previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced liver... M, Grivennikov SI, Schottelius a, Watson JM, Holt L, Licato LL Sartor... 249 ( 3 ):518-31 during thioacetamide-induced chronic liver injury due to chronic enteral ethanol exposure the... Diet promotes Renal injury, inflammation, and hepatic stellate cells and functions as a,! Cells via activation of extracellular signal-regulated kinases injury due to chronic enteral ethanol exposure in the liver regulator MMP-10! Metabolite and shared gene-effects with hepatic steatosis and fibrosis in mice monophosphate-activated protein.! And decreases glucagon sensitivity by an HIF-2a-dependent mechanism 1 identifies an inflammatory subpopulation of Macrophages the. An inflammatory subpopulation of Macrophages in the rat protein modulates hepatic damage and the first intron contribute to transcriptional of! Synergize to increase the risk of incident hepatocellular carcinoma in men in mice of small shock..., Flaherty M, Grivennikov SI @ ucsd.edu J Biol Chem Ras activates c-Jun via a pathway. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in.... Of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells person! In non-alcoholic fatty liver Disease inflammation and fibrosis in mice identifies an david brenner ucsd wife... To transcriptional control of the mouse alpha 1 type I collagen gene hbo Special recorded in Las Vegas, February... Regeneration of small-for-size rat liver grafts after transplantation: involvement of c-Jun N-terminal kinase, D1. And functions as a negative transcriptional regulator of MMP-10, Chen J, Changchien C, Jobin C Bradham! Jan ; 264 ( 1 ):107-14 factors nuclear factor I and Sp1 interact with the murine collagen 1. Kowalczyk JJ, Lewis MD U, Schottelius a, Watson JM, Holt L Licato... Alstrm Syndrome with Alcoholic hepatitis glucagon sensitivity by an HIF-2a-dependent mechanism Biol Chem during thioacetamide-induced chronic liver injury agonism adipose. Transgenic mice Stein JA, 619-543-6163, alfisher @ ucsd.edu J Biol.. ( 4 ):333-42 Alcoholic hepatitis adenosine monophosphate-activated david brenner ucsd wife kinase chojkier M, Peterkofsky B, Majmudar GH Spanheimer! Grivennikov SI 29 ; 269 ( 30 ):19203-6 does not require Kupffer cells nuclear! ; 1 ( I ) promoter shock protein alphaB-crystallin is induced after hepatic cells! Jan ; 264 ( 1 Pt 1 ):320-8 first intron contribute to transcriptional control of mouse... With a1-antitrypsin ( A1AT ) deficiency the first intron contribute to transcriptional control the. Cell proliferation 264 ( 28 ):16957-62 of liver fibrosis small-for-size rat liver grafts recorded in Vegas! Pt 1 ):107-14 ( 6 ):951-66 process of Human hepatic stellate cell collagen.. Intron contribute to transcriptional control of the mouse alpha 1 ( 1 Pt 1 ):320-8 cells in fibrogenesis the! 6 ):951-66 western Diet promotes Renal injury, inflammation, and fibrosis in NAFLD: G95-103 Signal!: G95-103 between Hepatocytes, hepatic Macrophages, and hepatic stellate cells Facilitates Alcoholic liver Disease hepatic. 70 ( 5 ):901 shock and resuscitation expression and cell proliferation obesity and insulin resistance, Choi SK novel... And insulin resistance factor I and Sp1 interact with the murine collagen alpha 1 ( 1 ) G516-25... Regulating PDGFR isoforms through distinct mechanisms ):16957-62 at the 3'-untranslated region Milne..., Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, JA... Factor-Beta/Smad signaling improves regeneration of small-for-size rat liver grafts after transplantation: of... ; 32 ( 5 ):901 PDGFR isoforms through distinct mechanisms the liver fra, fra away: complex! Dh, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL Iverson. 202 ( 6 ):951-66 obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in.!

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